|Synthetic Methods using Propiolic Acids & High Throughput Screening for Coupling Reactions|
: 153 : 2017.04.12 13:15
|일시 : 2017.04.12 17:00|
|소속 : 전남대학교 화학과|
|발표자 : 이선우|
|장소 : AS510|
We reported the decarboxylative coupling of alkynyl carboxylic acids and aryl halides using a palladium catalyst, which provides an efficient method for the synthesis of unsymmetrical and symmetrical diaryl alkynes. Aryl alkynes are important building blocks in the preparation of pharmaceutical and conjugated functional materials. The employment of alkynyl carboxylic acids as an alternative to terminal alkynes provides a very useful tool in the handling of alkynes with a low boiling point. Since we first reported the decarboxylative coupling reactions, a variety of such reactions involving alkynyl carboxylic acids have been reported by many research groups. Herein, we discuss a number of coupling reactions which are related to the decarboxylative couplings of propiolic acids including the selective coupling reaction, the multicomponent reactions and the carbonylations. In addition, we also developed the metal-free decarboxylative coupling reaction for the synthesis of allyl amines.
The development of efficient reaction conditions often requires many rounds of screening. This can be especially true in the case of metal-catalysed couplings, such as the always-popular palladium-catalyzed cross couplings, where it may be necessary to investigate the metal source, ligand, solvent, reaction temperature and bases as well as other additives. Because of the demand for the fast analysis of reaction leads to synthetic methodology development, we developed colorimetric analysis methods using gold nanoparticles, chemosensor and paper based colorimetric iodide sensor (PBCIS). In this seminar, the recent developed high throughput screening protocol will be presented.