Perspectives on Applied Chemistry: Quo Vadis Real Chemistry in Korea?

조회수 : 194 등록일 : 2016.09.28 09:52

일시 : 2016.09.28 17:00
소속 : 경희대학교 화학과
발표자 : 김정안
장소 : AS510
Irrespective of applied or pure chemistry, chemistry is inevitably fundamental and basic science. However, recent chemistry is completely distorted to be applied as the apparatus to obtain some items just used in the display field. In this respect, this presentation will cover a perspective on applied chemistry and its practical field of chemistry. Recent progress in the applied chemistry fields such as energy-saving and bio-related field including the polymeric materials will be discussed. In relation with the synthesis of polymeric compounds with well-defined structures, the importance of “living” polymerization will be discussed. For instance, poly(ethylene oxide) (PEO) has received a great deal of attention in the biomedical field because of its low level of cell and protein adsorption.1 In relation with its application field, PEO has been used as a key material for the modification of proteins, the synthesis of drug-conjugates, and the preparation of nanocarriers in the drug delivery system. However, it is not simple to obtain well-defined PEO with controlling the molecular weight and carrying functional groups at the chain-end. Up to date, the best method to synthesize PEO with well-defined structure has been known to be “living” anionic ring-opening polymerization of ethylene oxide leading to the generation of poly(ethylene oxide) (PEO) and the quantitative  chain-end functionalizations of the resulting polymer.2,3 In recent we have tried to develop new method for the preparation of heterobifunctional PEOs using commercial functional initiators. In relation with a quantitative heterobifunctionality, ring-opening polymerization of EO using a variety of functional initiators and chain-end functionalizations of the resulting polymers are expected to be the best way to obtain heterobifunctional PEOs as shown in Scheme 1.
 Scheme 1
1.  Vllasaliu, D.; Fowler, R.; Stolnik, S. Exp. Opin. Drug Del. 2014, 11, 139-154.
2.  Quirk, R. P.; Kim, J.; Kausch, C.; Chun, M. Polym. Int. 1996, 39, 3-10.
3.  Maeng, J. H. et. al. Biomaterials 2010, 31, 4995-5006.
  • 목록보기
  • 이전글보기
  • 다음글보기