Chasing Phosphohistidine, "Dark Matter" in the Phosphoproteome

조회수 : 257 등록일 : 2015.10.30 10:32

일시 : 2015.10.28 17:00
소속 : UNIST 화학과
발표자 : 기정민
장소 : R404
My research program focuses on the synergistic combination of synthetic organic chemistry and protein chemistry for innovative applications in biology and medicine. I will discuss our recent work on phosphohistidine (pHis), a labile protein post-translational modification (PTM). Despite the long-recognized importance of pHis in cell signaling and metabolism, the full scope and exact function of protein histidine phosphorylation is not clearly understood. It is mainly due to the chronic lack of adequate research tools to investigate the unstable PTM. We provided first glimpse at this “dark matter” in the phosphoproteome through the development of novel chemical tools for studying histidine phosphorylation, including stable pHis analogs, pHis-specific antibodies, and bisubstrate analogs for histidine kinases.
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