Publication

Fabrication of Wettability-Patterned Surface for Cellular Micropatterning Using Step-Wise Ion Beam Processing

조회수 : 371 등록일 : 2019.04.15 00:00

저자 : Shin, K (Shin, Kwanwoo)
출처 : JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
출판일 : 2019.08.01


Fabrication of Wettability-Patterned Surface for Cellular Micropatterning Using Step-Wise Ion Beam Processing


Hwang, IT (Hwang, In-Tae)1 ] Sohn, JY (Sohn, Joon-Yong)1 ] Jung, CH (Jung, Chan-Hee)1 ] Shin, J (Shin, Junhwa)1 ] Shin, K (Shin, Kwanwoo)2 ] Choi, JH (Choi, Jae-Hak)3 ]


[ 1 ] Korea Atom Energy Res Inst, Adv Radiat Technol Inst, Jeongeup Si 580185, Jeollabuk Do, South Korea
[ 2 ] Sogang Univ, Dept Chem, Seoul 121742, South Korea
[ 3 ] Chungnam Natl Univ, Dept Polymer Sci & Engn, Daejeon 305764, South Korea



In this study, the fabrication of a wettability patterned surface for cellular micropatterning was investigated using step-wise ion beam processing. A perfluorinated poly(ethylene-co-propylene) (FEP) film was first irradiated using accelerated Xe+ ions with 100 keV of energy at the low current density of 1 mu A/cm(2) over the entire surface. Second, its confined regions were irradiated at the higher current density of 15 mu A/cm(2) at various ion fluences through the pattern mask to generate patterns with big differences in wettability. From the analytic results, it was clearly verified that the step-wise irradiation induced effective chemical and morphological changes on the FEP surface, resulting in the successful formation of well-defined micropatterns with relatively hydrophilic and superhydrophobic surfaces. Moreover, the results of in-vitro cell culture showed well-resolved formation of 200 mu m cell micropatterns on the wettability patterned FEP surface due to the individual effects of the relatively hydrophilic and superhydrophobic properties on the cell adhesiveness and proliferation.






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