Publication

Asymmetric Synthesis of cis-5-(Aminomethyl)-3-(4-methoxyphenyl)dihydrofuran-2(3H)-one

조회수 : 71 등록일 : 2019.04.15 00:00

저자 : Lee, WK (Lee, Won Koo)
출처 : SYNTHESIS-STUTTGART
출판일 : 2019.02.15


Asymmetric Synthesis of cis-5-(Aminomethyl)-3-(4-methoxyphenyl)dihydrofuran-2(3H)-one


Kim, S (Kim, Sonhwan)1 ] Lee, WK (Lee, Won Koo)2 Ha, HJ (Ha, Hyun-Joon)1 ]


[ 1 ] Hankuk Univ Foreign Studies, Dept Chem, Yongin 17035, South Korea
[ 2 ] Sogang Univ, Dept Chem, Seoul 04107, South Korea



The asymmetric synthesis of (3R,5S )-5-(aminomethyl)-3-(4-methoxyphenyl)dihydrofuran-2(3 H )-one, as the most potent selective inactivator of monoamine B, was successfully achieved by applying a newly developed synthetic method toward the key -aminomethyl--lactone via intramolecular aziridine ring opening in 63% overall yield from a commercial starting material.






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