Publication

Future Research Directions in the Design of Versatile Extracellular Matrix in Tissue Engineering

조회수 : 102 등록일 : 2018.10.15 00:00

저자 : Setiawati, A (Setiawati, Agustina), Shin, K (Shin, Kwanwoo)
출처 : INTERNATIONAL NEUROUROLOGY JOURNAL
출판일 : 2018.07.31


Future Research Directions in the Design of Versatile Extracellular Matrix in Tissue Engineering


Setiawati, A (Setiawati, Agustina)1,2,3,4 ] Nguyen, HT (Huong Thanh Nguyen)1,2 ] Jung, Y (Jung, Yeongheon)1,2 ] Shin, K (Shin, Kwanwoo)1,2 ]


[ 1 ] Sogang Univ, Dept Chem, 35 Baekbeom Ro, Seoul 04107, South Korea
[ 2 ] Sogang Univ, Inst Biol Interfaces, 35 Baekbeom Ro, Seoul 04107, South Korea
[ 3 ] Sanata Dharma Univ, Fac Pharm, Yogyakarta, Indonesia
[ 4 ] Sogang Univ, Dept Life Sci, Seoul, South Korea



Native and artificial extracellular matrices (ECMs) have been widely applied in biomedical fields as one of the most effective components in tissue regeneration. In particular, ECM-based drugs are expected to be applied to treat diseases in organs relevant to urology, because tissue regeneration is particularly important for preventing the recurrence of these diseases. Native ECMs provide a complex in vivo architecture and native physical and mechanical properties that support high biocompatibility. However, the applications of native ECMs are limited due to their tissue-specificity and chemical complexity. Artificial ECMs have been fabricated in an attempt to create a broadly applicable scaffold by using controllable components and a uniform formulation. On the other hands, artificial ECMs fail to mimic the properties of a native ECM; consequently, their applications in tissues are also limited. For that reason, the design of a versatile, hybrid ECM that can be universally applied to various tissues is an emerging area of interest in the biomedical field.






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