Publication

Head-to-head comparison of F-18-FP-CIT and I-123-FP-CIT for dopamine transporter imaging in patients with Parkinson's disease: A preliminary study

조회수 : 135 등록일 : 2018.07.12 00:00

저자 : Chi, DY (Chi, Dae Yoon)
출처 : SYNAPSE
출판일 : 2018.07.28


Head-to-head comparison of F-18-FP-CIT and I-123-FP-CIT for dopamine transporter imaging in patients with Parkinson's disease: A preliminary study


Lee, I (Lee, Inki)1 ] Kim, JS (Kim, Jin Su)2 ] Park, JY (Park, Joon Yeun)1 ] Byun, BH (Byun, Byung Hyun)1 ] Park, SY (Park, Su Yeon)3 ] Choi, JH (Choi, Joon Ho)1 ] Moon, H (Moon, Hansol)1 ] Kim, JY (Kim, Jung Young)2 ] Lee, KC (Lee, Kyo Chul)2 ] Chi, DY (Chi, Dae Yoon)4 Kim, KM(Kim, Kyeong Min)2 ] Lim, I (Lim, Ilhan)1 ] Kang, JH (Kang, Joo Hyun)2 ] Ahn, SH (Ahn, Soon Hyuk)5 ] Kim, BI (Kim, Byung Il)1 ] Ha, JH (Ha, Jeong Ho)3 ] Lim, SM (Lim, Sang Moo)1 ]


[ 1 ] Korea Inst Radiol & Med Sci, Dept Nucl Med, Korea Canc Ctr Hosp, Seoul, South Korea
[ 2 ] Korea Inst Radiol & Med Sci, Res Inst Radiol & Med Sci, Div RI convergence Res, Seoul, South Korea
[ 3 ] Korea Inst Radiol & Med Sci, Dept Neurol, Korea Canc Ctr Hosp, Seoul, South Korea
[ 4 ] Sogang Univ, Dept Chem, Seoul, South Korea 
[ 5 ] Korea Inst Radiol & Med Sci, Radiopharmaceut Prod Ctr, Seoul, South Korea



I-123-FP-CIT and F-18-FP-CIT are radiotracers which are widely used to diagnose Parkinson's disease (PD). However, to our knowledge, no studies to date have made head-to-head comparisons between I-123-FP-CIT and F-18-FP-CIT. Therefore, in this study, I-123-FP-CIT SPECT/CT was compared with F-18-FP-CIT PET/CT in the same cohort of subjects. Patients with PD and essential tremor (ET) underwent I-123-FP-CIT SPECT/CT and F-18-FP-CIT PET/CT. Visual and semiquantitative analyses were conducted. The specific binding ratio (SBR) and putamen to caudate ratio (PCR) were compared between subjects who underwent I-123-FP-CIT SPECT/CT and F-18-FP-CIT PET/CT. Visual analysis showed that the striatal uptake of both radiotracers was decreased in the PD group, whereas striatal uptake was intact in the ET group. The SBR between I-123-FP-CIT SPECT/CT and F-18-FP-CIT PET/CT showed a positive correlation (r=.78, p<.01). However, the mean SBRs on F-18-FP-CIT PET/CT were higher than those on I-123-FP-CIT SPECT/CT (2.19 +/-.87 and 1.22 +/-.49, respectively; p<.01). The PCRs in these two modalities were correlated with each other (r=.71, p<.01). The mean PCRs on F-18-FP-CIT PET/CT were not significantly higher than those on I-123-FP-CIT SPECT/CT (1.31 +/-.19 and 0.98 +/-.06, respectively; p=.06). These preliminary results indicate that the uptake of both I-123-FP-CIT and F-18-FP-CIT was decreased in the PD group when compared with the ET controls. Visual analyses using both methods did not affect the diagnostic accuracy in this study. However, semiquantitative analysis indicated a better contrast of F-18-FP-CIT PET/CT relative to I-123-FP-CIT SPECT/CT.








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