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Synthesis of N-unsubstituted 1,2,3-triazoles via aerobic oxidative N-dealkylation using copper(II) acetate

조회수 : 70 등록일 : 2017.06.02 00:00

저자 : Cha, H (Cha, Hyojin); Chi, DY (Chi, Dae Yoon)
출처 : TETRAHEDRON
출판일 : 2017.05.18
 
 
Synthesis of N-unsubstituted 1,2,3-triazoles via aerobic oxidative N-dealkylation using copper(II) acetate
 
 
Cha, H (Cha, Hyojin)[ 1 ] ; Lee, K (Lee, Kyongkyu)[ 1 ] ; Chi, DY (Chi, Dae Yoon)[ 1 ]
 
 
[ 1 ] Sogang Univ, Dept Chem, 35 Baekbeomro Mapogu, Seoul 04107, South Korea
 
 
 
A copper-catalyzed aerobic oxidative C-N bond cleavage reaction was developed for the synthesis of 4-substituted-NH-1,2,3-triazoles. Diverse beta-ketotriazoles derivatives, which are the starting materials for the aerobic oxidative C-N bond cleavage reaction, were prepared from nine aryl and seven alkyl alkynes and alpha-azidoacetophenone by a copper(l)-catalyzed [3 + 2]cycloaddition reaction. The aerobic oxidation of alpha-(1,2,3-triazol-1-yl)acetophenones using a catalytic amount of copper(II) acetate in the presence oxygen under neutral conditions gave the title compounds in high yield. (C) 2017 Elsevier Ltd. All rights reserved.
 
 
 
 
 
 
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