|Synthesis of pyrrolo[2,1-f][1,2,4]triazin-4(3H)-ones: Rearrangement of pyrrolo[1,2-d][1,3,4]oxadiazines and regioselective intramolecular cyclization of 1,2-biscarbamoyl-substituted 1H-pyrroles|
: 159 : 2016.10.03 00:00
|저자 : Son, K (Son, Kkonnip)|
|출처 : BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY|
|출판일 : 2016.08.09|
[ 1 ] KRICT, Res Ctr Med Chem, 141 Gajeong Ro, Daejeon 305600, South Korea
[ 2 ] Sogang Univ, Dept Chem, 35 Baekbeom Ro, Seoul 121742, South Korea
Pyrrolo[2,1-f][1,2,4]triazin-4(3H)-ones 12 have been easily prepared via nucleophile-induced rearrangement of pyrrolooxadiazines 11 and regioselective intramolecular cyclization of 1,2-biscarbamoyl-substituted 1H-pyrroles 10. In this work, we demonstrated that the described synthetic approaches can be considered to be more facile and practical than previously reported procedures.