Publication

Mechanical stimuli responsive and highly elastic biopolymer/nanoparticle hybrid microcapsules for controlled release

조회수 : 208 등록일 : 2016.08.02 00:00

저자 : Shin, K (Shin, Kwanwoo)
출처 : JOURNAL OF MATERIALS CHEMISTRY B
출판일 : 2016.08.01
 
Mechanical stimuli responsive and highly elastic biopolymer/nanoparticle hybrid microcapsules for controlled release
 
 
Rajamanickam, R (Rajamanickam, Raja)[ 1 ] ; Baek, S (Baek, Siyeon)[ 2,3 ] ; Gwon, K (Gwon, Kihak)[ 1 ] ; Hwang, YM (Hwang, Youngmin)[ 1 ] ; Shin, K (Shin, Kwanwoo)[ 2,3 ] ; Tae, G (Tae, Giyoong)[ 1,4 ]
 
 
[ 1 ] Gwangju Inst Sci & Technol, Sch Mat Sci & Engn, 123 Cheomdangwagi Ro, Gwangju 61005, South Korea
[ 2 ] Sogang Univ, Dept Chem, Seoul 04107, South Korea
[ 3 ] Sogang Univ, Inst Biol Interfaces, Seoul 04107, South Korea
[ 4 ] KIST, Biomed Res Inst, Ctr Theragnosis, Seoul 02792, South Korea
 
 
Mechanical stimulus is one of the universally accessible physical ways of triggering the drug release from their carriers. Hollow microcapsules made of polyelectrolyte multilayers by conventional methods are not elastic enough to respond to a large and repetitive mechanical deformation. Here, hybrid hollow capsules comprising alternating layers of inorganic colloidal particles and biopolymers were prepared by the layer-by-layer approach followed by freezing-assisted crosslinking of polymer layers. The size of the capsule was controllable by the size of sacrificial cores. These hybrid capsules were mechanically more stable and recover faster than polyelectrolyte capsules, and could be recovered elastically even after large and repetitive deformation up to 98% relative to their original dimensions. Drugs in a wide range of molecular weight up to 70 kDa M-w could be loaded into the hollow hybrid microcapsules and the release of loaded contents from these hybrid capsules could be controlled through the deformation by applying a weak force such as a finger pressing on them. Mechanical stimuli-responsive delivery of model drugs was demonstrated on a monolayer of these hybrid capsules.
 
 
 
 
 
 
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